Best binary options signals

As a result, this slower trader-directed method of observing signals and then trading on them differs substantially from the algorithm-based and fully automated trading robots you might have run as expert advisors on MetaTrader4 or other platforms. Some quick facts before we launch into the best providers on the market: Some binary signal providers get around the possible trade execution delays this method can cause due to inattention by traders by having proprietary websites that clients monitor to get trade signals in a more timely way.

The Best Binary Options Signal Providers

Signals 365 is a well-established binary option signal service which offers an impressive 50-100 signals per day and claims to have a respectable win rate of up to 70%.

Binary Today 5 offers a binary option signal generation software package with some interesting features that differ considerably from what other binary option signal providers bring to the table.

First of all, you can use any broker, currency pair or trading session you want, since you call the shots as the trader. Second, using this service requires an one-time purchase of downloadable software to generate the trading signals locally based on its proprietary algorithm.

Binary options signals are trading alerts provided by a company or individual that has experience and expertise in binary options trading to less experienced traders, or traders who may not be able to devote time to market analysis.

Top binary options signals services allow newbies and inexperienced traders make money from trading. In fact, even experienced traders can do with a bit of help. Most trading ideas come through synthesis and by subscribing to reputable signal providers, an expert trader can improve the accuracy and win rate of his or her trading system.

Virtnext: This is another top binary options signals auto-trader. If you dont want manual signals that you have to implement yourself, then auto-traders are best. The trading is done for you. However, you have to monitor the software to ensure it is working as it ought to. It is necessary to do this since market conditions change and the software might not be able to adapt. Constant monitoring is necessary.

SignalPush: Signal Push is an auto, copy trading platform. The service allows you to access various signal providers and copy their trades. You can view the win rates and fees for the various services and decide whether to subscribe. Signal Push is highly recommended for its transparency. Statistics to help you make a decision to subscribe again are displayed.

What are binary options trading signals?

Binary signals are the result of market analysis it could be technical analysis or fundamental analysis. Signal gives trader information about the current market situation. Signals information depends on a special signal robot algorithm. Binary option robot analysed the market in real-time and when the algorithm condition is fulfilled signal send to an user. Read more at Best binary options signals.

Binary options trading strategies

Indicators and signals of binary options are very popular among novice traders in their deceptive simplicity: Traders think they do not need to study the market and the theory. They just open the position when they see an arrow up or down and think that is all they need. In most cases, this only leads to a quick loss of the deposit and all beginners should understand that they cant trade without thinking, analyzing the market and understanding what is the forex market is. Only that trades who have a trading strategy can win on the binary options market.

Pip365: This top binary options signals provider is good for binary options traders from the United States. They provide a browser based service and are great for traders who prefer to carry out trades on their own. Historical accuracy rates have been between 70-75%.

By using the above top binary options signals providers, you can kick start your vehicle of success in the market. There is no need to do the heavy lifting yourself. There is no need to make losses while learning about trading. You can work on your trading education while using the trading signals to make some profits in the meantime. Once you are more experienced, you can refine your trading ideas with the help of the signals.

Finance ,

Do you need more Instagram likes ?

Instagram likes, everyone want them People want to be popular on Instagram and for that they need more followers. Know your audience. Like: your target customer, their interests, and who they follow. Create a persona to target your content. Listen closely. Tailor your content based on how your audience is engaging with theirs. Use hashtags. We talked about this above. Don’t skip it.

Quality photos : This might seem like a no-brainer, but you’d be surprised how many people don’t do it. You don’t need a DSLR worth several thousand dollars to make a great Instagram post, but you should at least make sure your lighting is good and everything is in focus. I’d recommend at least a modern smartphone (like a newer iPhone or Galaxy) if you want to take some great-looking shots. Great photos are naturally more aesthetically pleasing – and that means more likes.

Though it’s not nearly as strict as Facebook, Instagram can be tough on brands looking to increase their reach organically. Taking advantage of the Instagram Ads platform to promote your posts helps you reach people that don’t already follow you. Its powerful targeting options (it’s the same as the Facebook Ads platform) allows you to select with pinpoint precision the people who will see your ads. If your targeting is sound and your content is engaging, you can bet you’ll gain more followers who are interested in your business, which means more likes. If none of this works you might explore automatic Instagram likes.

You can tag Instagram users in your post. Only do this if the person or business is relevant to your content. You don’t want to come across as spammy. However, people usually appreciate the recognition. They’ll usually respond with a like or a comment if you’ve mentioned them by name. It’s a great way to create relationships.

The caption area of your posts is often overlooked. Some folks write just a few words to sum up their posts and then publish. This can be a mistake. You have the chance to tell a story, invoke a feeling or create a message with this space. Use it wisely to help drive your marketing goals and to gain more likes. People are incentivized to click that heart on posts that affect them. Take time to make sure your captions do just that.

We like to humanize our company Instagram profile as much as possible while keeping a work and play balance. When marketing ourselves and our services, we recognize it is important for potential clients to understand who we are as a company as well as our friendly, positive outlook on all things digital marketing. We do this through ensuring a feature of several members of the team on the Instagram page — whether it’s a boomerang or engaging image — to give an insight into daily office life. Instagram stories also help users to connect with our company on a deeper level.

Internet

Powerful free Mac data recovery software

There are a number of Mac data recovery software options available, find out which data recovery app can recover the lost or deleted files on your Mac hard drive, SSD, or external storage device.

Key attribute of an ideal mac data recovery software : Data recovery from all types of storage SSDs, hybrid drives, hard drives, flash storage, SD cards, etc.

Let’s check a few of the apps: MiniTools from MiniTool Solutions will only let you recover 1MB of data before paying for the app, but it does at least offer you a 30-days money back guarantee, so if it doesnt do the job you should be able to recover your money (although maybe not your data).

Disk Drill is the free top data recovery app for Mac OS X. Disk Drill Basic, in addition to having previewing capabilities for recovered files, contains several other functionalities, such as Recovery Vault and Guaranteed Recovery, lost partition restoration, boot disk maker and so on, which make it one of the best Mac data recovery software applications available.

Recovery Vault is an advanced extra layer to the Trash Bin that keeps a reference to deleted data. Guaranteed Recovery is a background service that saves a copy of each file to an user-specified folder. Both data protection modules substantially reduce the possibilities of permanently losing critical data.

What we recommend:

Do Your Data Recovery for Mac Free 6.7 – Efficient free Mac data recovery software to completely recover lost files from Mac hard drive or storage device due to deleting, formatting, volume loss, OS crash, power failure etc. free Mac data recovery software. Do Your Data Recovery for Mac Free is the most reliable free Mac file recovery software that can recover lost files from both Mac machines and storage media. It is very simple to use, only three steps to get your lost files back.

Step 1: Select file types that you want to recover – All File Types are selected by default. If you only want to recover one or two or three etc file types of files, please select them on the interface. For example, if you only want to recover photos, you just only select ‘Images’, then the program will scan your drive or device and find only photos/images for you. It will save your time and get more focused scanning results.

Step 2: Select the drive or device where you lost files – Select the drive or device where you lost your files to start scanning. You can recover lost files from local/external Mac hard drive, as well as retrieve lost files from SD card, USB drive, digital camera, memory card or other storage media. You can even recover lost files from deleted/lost Mac volumes.

Step 3: Preview the files and recover them – You can preview the files to check their quality before recovery. Then recover what you want and save them on your computer or storage device. Please don’t save the found files on the disk where you lost your data, in case you overwrite the original data.

Do Your Data Recovery for Mac Free is the easy-to-use, efficient yet powerful Mac data recovery freeware. It can help you easily and completely recover deleted, formatted or inaccessible files from hard drive or storage media. Just download the free Mac data recover software – Do Your Data Recovery for Mac Free to get all lost data back with ease More info on data recovery for Mac free.

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Indonesia online gambling tips

Online gambling winning tricks… everyone wants to win at casino! Look for loose online slots : We have all heard at some point or another the term ‘loose slot’. This goes back to the time when mechanical slot machines had some mechanical defect that would make the slot loose, and therefore, more likely to pay out more often. In today’s world of online slots as well as random number generators, there is some truth to this theory. One of the secrets on how to win an online slot is to look at the rate of how frequently they pay out.

How to Play Casino Games Most Effectively : Take regular breaks when playing online casino games in order to focus better and keep your concentration in peak condition with a fresh brain.

Scratch Card Options: A lot of players love to play online scratch card games for some quick fun. While scratch cards can’t compete with the latest Sots online, some of the highest rated Casinos give you access to scratch card video games that are truly impressive. If scratch cards are the only online games you care about, you should also look at this article titled “Win Money Instantly with 30+ Free Scratch Cards” where we collected all the best real money games you can play in 2019.

Can You Win At Online Casinos? Of course you can! Part of the huge popularity of playing online comes from the many ways players can win real cash fast. From the big name progressive jackpots that run to thousands and millions, classic table games online, and the bingo and lotteries games, you’ll find a game to suit your taste. Gambling sites take great care in ensuring all the games are tested and audited for fairness so that every player stands an equal chance of winning big. Source: https://axiooplay.com/.

Ensure site’s legality and safety. All new casino sites offering gaming to the United States must acquire a legal gambling license to operate. Fortunately, anyone playing with new sites listed on we can rest assured every site is secure, safe and fully regulated. Check out the user experience. The player’s experience while enjoying the site can be a huge factor to certain people and essentially makes or breaks the product as whole. Ensuring a new site is responsive, fast and easy to navigate it crucial when evaluating where to sign-up. Investigate the game offerings. If a casino isn’t established it might not have partnerships with the most elite game providers to be sure to check what games and what providers are featured throughout the site. A demo or free play mode is always helpful in the process and typically offered with a top casino sites.

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Online Casinos

Talk satisfactions and chat avenue

Online chat rooms and talk advantages ? How talking to other people benefits your brain and well being? We will discuss this topic, showing some examples of how social connection can be beneficial to your life.

The most common spots for meeting friends online are social media sites like Facebook or Instagram (64% of teens who have made a friend online met someone via social media), followed by playing networked video games (36%). Girls who have met new friends online are more likely to meet them via social media (78% vs. 52% of boys), while boys are substantially more likely to meet new friends while playing games online (57% vs. 13% of girls). Do you want to lak with someone ?

Do you want a reason to talk to someone you don’t know ? The best part of talking to strangers is that you never know who you might meet. The person running on the treadmill next to you might have a job opportunity for you, they might be in the market for the piece of real estate you are trying to sell, they might run for president one day (who wouldn’t love being a close friend to the president), or they might end becoming your husband or wife. You have literally no idea what to expect from the interaction unless you actually step up and initiate a conversation with the stranger. By talking to them, you open up a world of numerous possibilities. You don’t know what opportunities you miss by keeping to yourself. Read more details on talk with stranger.

There is the associated question of whether the internet is splitting people into two separate worlds: online and offline. Originally, both those who worshipped the internet and those who feared it thought that people’s online relationships would be so separate from their existing relationships that people’s “life on the screen,” as Sherry Turkle put it in 1995, would be different from their “real life.” Is this the case? Or is the internet now an integral part of the many ways people relate to friends, relatives, and even neighbors in real life? Can online relationships be meaningful, perhaps even as meaningful as in-person relationships?

This point is loosely in relation to body language and voice tone. It is true that chat communication benefits you as you send unconscious messages to the other person through your body language. In addition, with chat communication, you can explain clearly and answer questions with integrity. If you are a manager, your employees are able to see clearly how your words and actions align. This will enhance your credibility and help build trust between you and the other person.

In one illustrative intervention study (Hampton & Wellman, 2003), a suburb of Toronto had been turned into a “wired suburb” when residents were offered a package of online services, including high-speed internet access, videophone, online health advice, and local online discussion forums. After this intervention, follow-up data suggested that the internet actually stimulates more offline contact (resonating with the debate reviewed above) and promotes collective action to solve community problems offline (see also Blanchard & Horan, 1998). Read more info at talk to random people.

Society

Create a local community to meet people

Create a local community to meet people on Communian. This website allows you to create a group and local events on any topic. Are you passionate about cycling? You can make a local cycling group and start organizing events! What are the benefits of local communities and how they help the human brain and soul? Self-Satisfaction: Nothing gives you a well-deserved sense of worth than investing in something important to you. Sharing the passion with others increases its viability while exploring next-level opportunities brings inspiration and confidence.

Huge interest based communities are local focused on Communian. Let’s take reddit for example: /r/buildapc Interested in setting up your own PC from scratch? Building your own instead of buying an off-the-shelf computer allows you to customize your rig to suit your preferences and save you some cash. This community is filled with enthusiasts showing off their latest builds, discussing new PC components and sharing advice on tackling common setup issues. There are loads of resources for first-timers, including an FAQ and guides for choosing components, assembling them and adding some finishing touches like installing essential apps and overclocking your new computer.

Communian is all about social connections. Create a social spot. Sometimes it can be difficult for employees to socialize because they don’t have an area in the office where they feel comfortable doing so. Creating a “social spot” for your employees will give them an area where they can decompress or socialize without distracting other colleagues. Consider repurposing an empty area at your company to create a Zen room or game room for employees to hang out over their breaks. If you don’t have a spare room to use, try setting up some chairs or couches by popular spots for socializing in the office – like the break room or the area by the water cooler. Utilize wellness challenges. Rather than focusing solely on wellness challenges at the individual level, start creating team wellness challenges. For example, a team walking challenge will challenge colleagues to come together and compete as a team to take more steps in one month than other departments. Daily walking clubs are another excellent idea that can also be used to encourage social connections.

By immersing yourself in a community, you also give yourself a chance to learn from the overall group, mining the wisdom of several people and helping each other out along the way. You can also create a mastermind group of trusted peers who give each other the advice and feedback every entrepreneur needs, especially those just starting their journeys. Read extra info on Join a local community to meet people and share your interests.

Social Sciences

Invisalign Ealing and some dentist advices

Do you want to maintain healthy teeth and gums? Here are a few tricks: Avoid using your teeth for anything other than chewing food. If you use them to crack nuts, remove bottle tops or rip open packaging, you risk chipping or even breaking your teeth. See your dentist for regular check-ups. You should also visit your dentist if you have a dental problem such as a toothache or bleeding gums.

We are proud to be a leading facial aesthetics expert in Ealing with a fantastic reputation for providing first class dermal filler and botox treatments. Our highly experienced facial aesthetic dentists are all registered with the General Dental Council (GDC) and our clinic is monitored and regulated by the Care Quality Commission (CQC), so you can rest assured you’re in safe hands with our expert dental team. If you’re looking for a trusted, highly experienced dermal filler expert in Ealing who offers premium quality results at affordable prices, then we can help. Our safe, effective and long lasting dermal filler treatments in Ealing have been successfully helping transform patients lips and cheeks for many years. Dermal fillers are an example of another non-surgical treatment which has been designed to rejuvenate your natural facial contours, smoothing out lines and adding volume to your lips and cheeks. See extra details on botox Ealing.

Use Activated Charcoal: Activated charcoal is one of the easiest and most inexpensive ways to naturally whiten your teeth. Crush up one charcoal tablet into a powder. Dip your clean wet toothbrush into it, and brush your teeth as you normally do.

The results you get from teeth whitening depend on what your teeth were like when you started. Some people think whitening erases all the damage they’ve done to their teeth over their lifetimes, but the opposite is true: The better you’ve cared for your teeth, the greater the results. The more you’ve maintained regular dental appointments, brushed and flossed regularly, and avoided damage and discoloration, the whiter your teeth will appear after a teeth whitening service. Source: https://www.thedentalgallery.co.uk/.

Health

Trends in hairstyle industry

Hairstyle “whats cool for” 2019. People who watched Netflix’s recent smash hit Russian Doll can’t stop talking about two things: that scary elevator scene and star Natasha Lyonne’s hair. More specifically, it’s her curly bangs that make everyone wonder if they too can try the gorgeous cut, whether they have naturally curly hair or not. Hairstylist Ted Gibson, the man behind Sandra Oh’s glorious fringe, previously told Allure that nailing curly bangs starts with a serious chat with your stylist. He also mentions they should be cut with scissors (held vertically) for “a softer edge.” Read More

Beauty

Why casino games got so hot in Indonesia lately?

The beauty of the internet is that it has made the world a much smaller place, giving you access to superior gaming content without having to leave your own home. Indonesian casino players now have many extremely popular online casino brands on hand to serve them, including judi bola casino at ibetsbobet.com.

But because of the development of online networking , its very easy nowdays to have fun , unrestricted, in internet enterteinment locations, thus bypassing the physical restrictions. This is the reason for the huge growth on Indonesian gambling activities in the past years.

Table games represent classic options that are still extremely popular in the modern age. However, the colourful options are the various Playtech slots that make up the library. Playtech has been responsible for the development of popular industry releases in the form of Battle of the Gods, Piggies & the Wolf, Desert Treasure 2, Sherlock Mystery, Fortune Hill, and Vikingmania.

Online gambling provides local citizens with the opportunity to play casino games, poker, bingo, as well as bet on world sport events. Still, a great variety of international websites provided by some of the world’s largest companies, which allow Indonesian players to enjoy their favorite pastime without leaving the safety and comfort of their homes.

More details about Indonesia :

Indonesia, officially the Republic of Indonesia is a sovereign island country located in Southeast Asia and Oceania. This is the world’s biggest island country consisting of more than 14,000 islands. Indonesia is the 4th most populous country in the world with an estimated population of 255 million. It is the most populous Muslim-majority country in the world. The country’s capital and largest city is Jakarta with approximately 30 million residents in its metropolitan area. The world’s most populous island is part of Indonesia called Java where approximately half of the countries population resides. The country’s official language is Indonesian. The officially recognized religions in the country are Islam, Protestantism, Catholicism, Hinduism, Buddhism, and Confucianism.

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Existing-Home Sales Soar 5.6 Percent in November to Strongest Pace in Over a Decade

Existing-home sales surged for the third straight month in November and reached their strongest pace in almost 11 years, according to the National Association of Realtors?. All major regions except for the West saw a significant hike in sales activity last month.

Lawrence Yun is chief economist and senior vice president of research at the National Association of Realtors(r). Yun oversees and is responsible for a wide range of research activity for the association including NAR’s Existing Home Sales statistics, Affordability Index, and Home Buyers and Sellers Profile Report. He regularly provides commentary on real estate market trends for its 1 million Realtor(r) members. (PRNewsFoto/National Association of Realtors)

Total existing-home sales1, https://www.nar.realtor/existing-home-sales, which are completed transactions that include single-family homes, townhomes, condominiums and co-ops, jumped 5.6 percent2 to a seasonally adjusted annual rate of 5.81 million in November from an upwardly revised 5.50 million in October. After last month’s increase, sales are 3.8 percent higher than a year ago and are at their strongest pace since December 2006 (6.42 million).

Lawrence Yun, NAR chief economist, says home sales in most of the country expanded at a tremendous clip in November. “Faster economic growth in recent quarters, the booming stock market and continuous job gains are fueling substantial demand for buying a home as 2017 comes to an end,” he said. “As evidenced by a subdued level of first-time buyers and increased share of cash buyers, move-up buyers with considerable down payments and those with cash made up a bulk of the sales activity last month. The odds of closing on a home are much better at the upper end of the market, where inventory conditions continue to be markedly better.”

The median existing-home price3 for all housing types in November was $248,000, up 5.8 percent from November 2016 ($234,400). November’s price increase marks the 69th straight month of year-over-year gains.

Total housing inventory4 at the end of November dropped 7.2 percent to 1.67 million existing homes available for sale, and is now 9.7 percent lower than a year ago (1.85 million) and has fallen year-over-year for 30 consecutive months. Unsold inventory is at a 3.4-month supply at the current sales pace, which is down from 4.0 months a year ago.

“The anticipated rise in mortgage rates next year could further cut into affordability if these staggeringly low supply levels persist,” said Yun. “Price appreciation is too fast in a lot of markets right now. The increase in homebuilder optimism must translate to significantly more new construction in 2018 to help ease these acute inventory shortages.”

First-time buyers were 29 percent of sales in November, which is down from 32 percent both in October and a year ago. NAR’s 2017 Profile of Home Buyers and Sellers – released earlier this year5 – revealed that the annual share of first-time buyers was 34 percent.

Matching the highest share since May, all-cash sales were 22 percent of transactions in November, which is up from 20 percent in October and 21 percent a year ago. Individual investors, who account for many cash sales, purchased 14 percent of homes in November, up from 13 percent last month and unchanged from a year ago.

“The elevated presence of investors paying in cash continues to add a layer of frustration to the supply and affordability headwinds aspiring first-time buyers are experiencing,” said Yun. “The healthy labor market and higher wage gains are expected to further strengthen buyer demand from young adults next year. Their prospects for becoming homeowners will only improve if more lower-priced and smaller-sized homes come onto the market.”

Properties typically stayed on the market for 40 days in November, which is up from 34 days in October but down from 43 days a year ago. Forty-four percent of homes sold in November were on the market for less than a month.

Realtor.com?’s Market Hotness Index, measuring time on the market data and listings views per property, revealed that the hottest metro areas in November were San Jose-Sunnyvale-Santa Clara, Calif.; Vallejo-Fairfield, Calif.; San Francisco-Oakland-Hayward, Calif.; San Diego-Carlsbad, Calif.; and Stockton-Lodi, Calif.

According to Freddie Mac, the average commitment rate for a 30-year, conventional, fixed-rate mortgage increased for the second straight month to 3.92 percent in November from 3.90 percent in October. The average commitment rate for all of 2016 was 3.65 percent.

On the topic of tax reform, NAR President Elizabeth Mendenhall, a sixth-generation Realtor? from Columbia, Missouri and CEO of RE/MAX Boone Realty, says it’s good news homeowners can continue to count on tax incentives such as the mortgage interest deduction and the state and local tax deduction.

“Only 6 percent of homeowners have mortgages exceeding $750,000, and only 5 percent pay more than $10,000 in property taxes, but most homeowners won’t itemize under the new regime,” she said. “While we’re pleased that important homeownership incentives such as the capital gains exclusion survived in conference, additional changes are required to truly incentivize homeownership in the tax code.”

Distressed sales6 – foreclosures and short sales – were 4 percent of sales for the fourth straight month in November, and are down from 6 percent a year ago. Three percent of November sales were foreclosures and 1 percent were short sales.

Single-family and Condo/Co-op Sales
Single-family home sales grew 4.5 percent to a seasonally adjusted annual rate of 5.09 million in November from 4.87 million in October, and are now 3.2 percent above the 4.93 million pace a year ago. The median existing single-family home price was $248,800 in November, up 5.4 percent from November 2016.

Existing condominium and co-op sales increased 14.3 percent to a seasonally adjusted annual rate of 720,000 units in November, and are now 7.5 percent above a year ago. The median existing condo price was $242,500 in November, which is 8.8 percent above a year ago.

Regional Breakdown
November existing-home sales in the Northeast leaped 6.7 percent to an annual rate of 800,000, (unchanged from a year ago). The median price in the Northeast was $273,600, which is 4.0 percent above November 2016.

In the Midwest, existing-home sales jumped 8.4 percent to an annual rate of 1.42 million in November, and are now 6.8 percent above a year ago. The median price in the Midwest was $196,100, up 8.8 percent from a year ago.

Existing-home sales in the South expanded 8.3 percent to an annual rate of 2.34 million in November, and are now 4.0 percent higher than a year ago. The median price in the South was $216,200, up 4.8 percent from a year ago.

Existing-home sales in the West declined 2.3 percent to an annual rate of 1.25 million in November, but are still 2.5 percent above a year ago. The median price in the West was $375,100, up 8.2 percent from November 2016.

The National Association of Realtors?, “The Voice for Real Estate,” is America’s largest trade association, representing 1.3 million members involved in all aspects of the residential and commercial real estate industries.

NOTE: For local information, please contact the local association of Realtors? for data from local multiple listing services. Local MLS data is the most accurate source of sales and price information in specific areas, although there may be differences in reporting methodology.

1 Existing-home sales, which include single-family, townhomes, condominiums and co-ops, are based on transaction closings from Multiple Listing Services. Changes in sales trends outside of MLSs are not captured in the monthly series. NAR rebenchmarks home sales periodically using other sources to assess overall home sales trends, including sales not reported by MLSs.

Existing-home sales, based on closings, differ from the U.S. Census Bureau’s series on new single-family home sales, which are based on contracts or the acceptance of a deposit. Because of these differences, it is not uncommon for each series to move in different directions in the same month. In addition, existing-home sales, which account for more than 90 percent of total home sales, are based on a much larger data sample – about 40 percent of multiple listing service data each month – and typically are not subject to large prior-month revisions.

The annual rate for a particular month represents what the total number of actual sales for a year would be if the relative pace for that month were maintained for 12 consecutive months. Seasonally adjusted annual rates are used in reporting monthly data to factor out seasonal variations in resale activity. For example, home sales volume is normally higher in the summer than in the winter, primarily because of differences in the weather and family buying patterns. However, seasonal factors cannot compensate for abnormal weather patterns.

Single-family data collection began monthly in 1968, while condo data collection began quarterly in 1981; the series were combined in 1999 when monthly collection of condo data began. Prior to this period, single-family homes accounted for more than nine out of 10 purchases. Historic comparisons for total home sales prior to 1999 are based on monthly single-family sales, combined with the corresponding quarterly sales rate for condos.

2 November’s monthly increase of 5.6 percent is the largest monthly gain since December 2015 (12.1 percent), which was influenced by delayed closings resulting from the rollout of the Know Before You Owe initiative in late 2015.

3 The median price is where half sold for more and half sold for less; medians are more typical of market conditions than average prices, which are skewed higher by a relatively small share of upper-end transactions. The only valid comparisons for median prices are with the same period a year earlier due to seasonality in buying patterns. Month-to-month comparisons do not compensate for seasonal changes, especially for the timing of family buying patterns. Changes in the composition of sales can distort median price data. Year-ago median and mean prices sometimes are revised in an automated process if additional data is received.

The national median condo/co-op price often is higher than the median single-family home price because condos are concentrated in higher-cost housing markets. However, in a given area, single-family homes typically sell for more than condos as seen in NAR’s quarterly metro area price reports.

4 Total inventory and month’s supply data are available back through 1999, while single-family inventory and month’s supply are available back to 1982 (prior to 1999, single-family sales accounted for more than 90 percent of transactions and condos were measured only on a quarterly basis).

5 Survey results represent owner-occupants and differ from separately reported monthly findings from NAR’s Realtors?Confidence Index, which include all types of buyers. Investors are under-represented in the annual study because survey questionnaires are mailed to the addresses of the property purchased and generally are not returned by absentee owners. Results include both new and existing homes.

6 Distressed sales (foreclosures and short sales), days on market, first-time buyers, all-cash transactions and investors are from a monthly survey for the NAR’s Realtors? Confidence Index, posted at nar.realtor.

NOTE: NAR’s Pending Home Sales Index for November is scheduled for release on December 27, and Existing-Home Sales for December will be released January 24; release times are 10:00 a.m. ET.

From https://www.prnewswire.com/news-releases/existing-home-sales-soar-56-percent-in-november-to-strongest-pace-in-over-a-decade-300573924.html

Real Estate

Furniture movers Calgary

You’ve got the keys. So now you need to move. Top moving house checklist tips including cleaning, utility bills, removal companies and redirecting mail. But here are some moving tips and tricks, to ease the stress.

Place an extra cotton pad or ball into your powder cosmetics to keep them from breaking. Read More

Business Presentation : House Cleaning Tuscaloosa

Maids In America isnt just one company trying to do everything we are a team of companies all under the same owner. Each team is dedicated to performing services they do best. In 2007 we opened our doors at Maids In America to begin small scale residential only maid service. In 2010 we added janitorial services, incorporated and added our first dedicated cleaning services office in Northport, Alabama.

In 2012 Maids In America added multiple dedicated divisions setup as individual companies. This put our cleaning company in a position to sustain.With over 200 reviews combined from our offices in Google and Facebook we are by far the cleaning quality leaders in Tuscaloosa County.

Company Divisions :

1. Maids In America
Residential homes and small to medium-small commercial cleaning services. The parent company for all divisions.
2. Engineered Clean
Residential homes and small to medium-small commercial cleaning services. The parent company for all divisions.
3. Maid Clean By Design
Maid Clean By Design specializes in cleaning challenging homes above 4000 square feet.
4. Instant Floor Clean
Instant Floor Clean specializes in carpet cleaning, tile & grout cleaning, and finished VCT floor re-finishing and restoration.

Our cleaning team is trained with visual cleaning charts and checks off visual cleaning charts as they clean.

– Consistent cleaning quality each and every visit
– Adults learn better visually Wharton School of Business
– With our visual system our cleaning team learns faster and cleans better

We developed the Visual Clean System to reduce the most common cleaning consistency issues and it works!

Services Presentation

Low Moisture Carpet & Tile Cleaning

Over time our carpet and tile cleaning techniques have evolved into a low moisture method using heat and agitation. Our powerful dual cylinder scrubbing machines use very little water yet generate tremendous heat and friction while lifting carpet fibers up. By lifting carpet fibers up the machine can remove all contaminants from your carpet all the way down to base of the carpet.

Contact Info for Maids In America East:

Website : https://maidsinamerica.com/maidserviceinformation/
Address : 3740 Hargrove Road East Tuscaloosa, Al 35405
Phone : 1-205-421-9934

Find used auto parts by searching junkyards near you

Yes. When you search junkyards near me, UsedPart.us will be there to help! At UsedPart.us we know all about finding used auto parts, used car parts, and used truck parts. With our help you can find any used auto part you need. Complete our PARTS FINDER form, we will search our database of over 10,000 junk yards, salvage yards, scrap yards, and recycle centers. Therefore, provide you with the lowest price guaranteed for your auto part or car and truck part, all while providing the industry’s best warranty for your peace of mind. UsedPart.us can help you find engines, transmissions, hoods, fuel pumps, truck beds, front nose assembly and more.

Searching for quality used auto parts has never been easier!

Everyone hates being told the used auto parts or used car parts they need is not in stock. Have you ever just wandered, “Are there any junkyards near me?” With our database you can find junkyards in the USA by zip code, you will hear yes! UsedPart.us understands the used auto parts search and processes down to a science, and have implemented various tools to help insure the process for you is a breeze. No matter the type: new, older, classic, muscle, import, or custom made from different parts from different makes and models! We want to help you find the used auto part and used car part you are looking for. Go green and recycle, which will help reduce humans carbon foot print on the earth. You will also see more green in your wallet also which is a win-win.

You get the freedom to find the best price and warranty that best fits your needs. Locate junkyards in the USA by zip code, or by state for used auto parts with the finest quality, it has never been easier. You have the power to source hard to find, quality used auto parts with our network of 8000 + junkyards throughout the United States. You are no longer stuck searching in just one area, because our network of junkyards covers all 50 states. Find junkyards by in the USA by zip code, state, or area code that are close to you very easily at UsedPart.us! Our company strives to provide excellent junkyard locating and used auto part sourcing, nationwide!? We only list junkyards listed with the ARA on our service.

Tips on Buying Used Auto Parts

We always recommend using O’reilly Auto Parts for any NEW auto and truck parts you may need! Try your luck today!

With over 10,300 junkyards in our database you can rest easy knowing you will find quality used auto parts. As part of the Auto Recycler’s Association, any junkyards found in your state will be in good standing. Providing quality, friendly service at an affordable price. Allow UsedPart.us to help you on your “junkyards near me” or “used auto parts near me” search today. When salvage yards work hard for your business you are almost guaranteed to get the best price!

Don’t feel like searching through each individual junkyard near you to find the part you are looking for? UsedPart.us has made it easier on you with our PARTS FINDER form. Locate parts across the country fast and for the best pricing available! We provide the best price for the auto part you are looking for. Review price, condition, warranty information, and other vital information about those quality used auto parts. Another great thing about our services, we that we will locate parts in the dry climate areas, and not in the rust belt or snow beaten states. This helps you rest easy, knowing the auto parts are not rusty or about to fall apart when received. At UsedPart.us we are all about selling customers used quality auto parts at an affordable price.

Don’t waste your time with long hold times, and poorly trained used car part brokers. They aim to make a profit off of you by marking up prices as much as 50%! Cut out the middleman and get the quality used car part you need at the best available price. Therefore, you can save an average of 35% to 50% of the “aftermarket part cost”! We have saved customers hundreds of thousands of dollars over the years with this convenient auto part search form, so why not join in on the savings today!

To get started, click on your state, enter your zip code in the search box provided, to get a map of all the junkyards in your area! The junkyards listed by state will have contact numbers provided along with addresses, and hours of operation when applicable.

You can search junkyards for auto parts in all US states :
Junkyards in delaware

Here at UsedPart.us, we have taken all of the junkyards in cities located across the United States and compiled them into our vast Junkyards Near Me Database. This vast collection of complied data gives the user complete control over finding junkyards in the city you choose. Not only do you get to choose to search junkyards by city, but within this search you can locate junkyards in distance by miles from your current location or just use your zip code. Each search quickly brings all the information you need up in a single page for a junkyard that fits your match. This information includes the name, street address, city, state and zip code with the telephone number and hours of operation when applicable. Finding junkyards and quality used auto parts has never been easier, so start searching today!

High quality TEFL courses in Madrid, Spain

Accredited top quality TEFL courses in Madrid, Spain? Here is the complete TEFL guide, with all you need to know in single post. Teaching English really is a great and rewarding self development path! It offers many avenues to independence, visiting, exploration, and a fun lifestyle.

Common misconception: teaching English abroad is always with youngsters who have never studies English. False! While many positions are orientated towards children who are giving English their first-go, there are many opportunities teaching adolescents and adults that have intermediate and advanced levels. That being said, you should be prepared to take on any age and level of learner. Teaching advanced students tends to be a little more generous to your wallet, too.

TEFL Madrid Academy is a well equipped training center that is committed to the highest professional standards. We don’t simply offer an internationally recognized TEFL certification to our students but we also prepare them for a fulfilling career teaching English. TEFL Madrid Academy is strategically located in the heart of Madrid, Spain, with easy access to the major attractions such as the Prado Museum, Retiro Park, the Royal Palace and the city’s shopping and business areas. Well communicated and surrounded by the main businesses and large corporations, once you graduate you will be ready to teach. We welcome you to have a virtual tour of our facilities. Following the course, all graduates of our TEFL course will continue to have our full support and access to the facilities and teacher tools at the school. See more info on Tefl Abroad.

Teaching English abroad is reasonably well paid in most countries, and some Asian and Arab countries pay excellent teaching rates. Good English teachers earn enough to live well in the local culture and make trips on their days off to explore neighboring countries. For example, if you decide to spend 6 months in Prague, you get travel to Berlin, London, Paris, Vienna, Budapest, Krakow and other beautiful cities in less than 2 hours. Many of your students will see English as a means to improve their lives – to get a new or better job, to travel, to get to know new cultures, to meet new friends, to be able to talk to their kids’ friends… You will literally open the doors of the world to them.

As mentioned above, we are committed to setting up as many interviews as possible with agencies from all over Madrid; we work with over 300. Also, we always provide job counselling for teachers who have just finished the course and who wish to use their TEFL for finding a job in Spain; help with preparing CVs, interview workshops where we teach our students how to show their best qualities and achieve the best possible results in an interview. Regarding finding a job, TEFL Madrid location is one of the best, as Madrid is one of the cities with the most job opportunities in Spain. There are teaching posts available all year round, although they are slightly higher at the start of terms (summer months and February). The average wage for a teacher in Spain is approximately 1500€, although this will vary depending on the type of centre. However, your possibilities for teaching are not restricted to Spain. Once you have your TEFL certification, you will be able to travel to any country you like to teach English. As it is the language most spoken in the world, as a native language and also as a second language, you will be able to live almost anywhere in the world. Visit: https://tefl-madrid.com/.

Business

Dentist recommendations for kids

Dental tips for kids? Control the Sippy Cup: A sippy cup can help kids move from a bottle to a glass, but don’t let him drink from it all day long. Using it too much can lead to decay on the back of the front teeth if the drinks are sugary.

Once they begin to erupt, brush teeth twice a day with a fluoride toothpaste in an amount no more than a smear the size of a grain of rice – use a soft-bristle toothbrush. Take the bottle away after your child finishes drinking to prevent baby bottle tooth decay. Baby bottle tooth decay can happen when babies drink milk, formula, or juice from bottles over long periods of time or fall asleep with the bottle.

If you are looking for a trusted, well respected children’s orthodontist in London offering top quality and affordable children’s braces then we can help. We are passionate and dedicated about providing the highest possible standard of paediatric dentistry, with modern, state of the art treatments in a child friendly, playful and relaxed atmosphere. All of our highly experienced orthodontists are members of the General Dental Council (GDC) and our practice is regulated and monitored by the Care Quality Commission (CQC), so you can rest assured your kids are in safe hands here at Toothbeary. We are proud to offer the very best in fixed and invisible children’braces as outlined below: Fixed braces consist of a series of small square attachments (brackets) cemented to the teeth. These brackets are highly sophisticated as every tooth has its own unique bracket design engineered to achieve optimal final tooth position and angulation. Discover extra info https://www.toothbeary.co.uk/paediatric-fixed-orthodontics-richmond-london.html.

Summer dental tip : As a London pediatric dentistry, we take our responsibility toward children’s dental health seriously and offer our easy-to-follow dental hygiene tips for parents to make sure your child’s smile stays happy and healthy. Pack a Toothbrush for Overnight Visits: If your child is sleeping over at a friend’s house or visiting grandma for the weekend, make sure that their children’s toothbrush and toothpaste is packed. If you’re worried grandma won’t enforce teeth brushing, we recommend buying your child an inexpensive toothbrush with their favorite character on it. This can provide an incentive for them to try out their new toothbrush during their weekend away.

Our unique approach to treating your child is designed to build trust and confidence through positive experiences, allowing us to promote and reinforce good oral hygiene habits whilst instilling the need to care for your teeth. Dedicated to getting to know your child and not just their symptoms, we aim to learn about any of their inhibitions, anxieties or fears in order to assess which of our methods is best for them. Our treatment methods include, but are not limited to “tell – show – do”, desensitisation, hypnotherapy, nitrous inhalation and I.V. / nasal sedation. Discover extra info https://www.toothbeary.co.uk/.

Dentistry

Levitra general overview

Viagra is approved to treat erectile dysfunction (ED), also known as impotence, in men. It increases blood flow to the penis following sexual stimulation and allows men to keep an erection hard enough for sex.

Before you take VIAGRA, tell your healthcare provider if you:

have or have had heart problems such as a heart attack,
irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
have had heart surgery within the last 6 months
have pulmonary hypertension
have had a stroke
have low blood pressure, or high blood pressure that
is not controlled
have a deformed penis shape
have had an erection that lasted for more than 4 hours
have problems with your blood cells such as sickle cell
anemia, multiple myeloma, or leukemia

Super Kamagra is used to treat erectile dysfunction and premature ejaculation, two of the most common sexual problems among men. Such conditions are more frequent to men ages 40 and above, thus creating the demographic for Super Kamagra. This drug is a powerful and potent medicine that contains dapoxetine and sildenafil citrate to promote erection and improved performance in bed.

Shop online Germany for Cialis DE – Potenzmittel! Kamagra Gold 100 MG Tablet relaxes the smooth muscles present in the wall of blood vessels and helps in increasing the flow of blood in certain specific areas of the body. It is used for the treatment of erection disorders and Pulmonary Hypertension (high blood pressure of blood vessels connecting the lungs and the heart).

Side effects
Major & minor side effects for Kamagra Gold 100 MG Tablet

Headache – severe
Flushing
Bloody nose
Indigestion – severe
Sleeplessness
Diarrhea
Dizziness – severe
Bloody and cloudy urine – severe
Burning, numbness, tingling in the arms and feet – severe
Changes in vision – severe – rare
Sensitivity to light – severe – rare
Prolonged and painful erection – severe – rare
Painful urination – severe

This medicine is not recommended for consumption by pregnant women unless clearly needed. Consult a doctor and discuss the benefits and risks before taking this medicine.

Use of alcohol should be avoided or kept to a minimal level while you are taking Kamagra Gold 100 MG Tablet. Symptoms like dizziness, fainting, flushing, persistent headaches should be reported to the doctor.

Interaction with Medicine

Amlodipine – moderate
Carbamazepine – moderate
Clarithromycin – severe
Dexamethasone – moderate
Ketoconazole – severe
Atazanavir – severe
Nitroglycerin – severe

Kamagra Gold 100 MG Tablet should be used with caution in patients suffering from a disorder of the retina in which color discrimination is impaired. Use of this medicine should be avoided in this cases.

Kamagra Gold 100 MG Tablet may cause a sudden decrease in hearing capabilities along with clinging sound in the ears and dizziness. Contact your doctor immediately if such symptoms are observed.

The risk of side effects is increasingly high in smokers, elderly and people suffering from conditions of heart disease, diabetes, high blood pressure, high cholesterol levels etc. Caution should be exercised in such cases. Some side effects like dizziness, numbness, nausea and pain could occur while having an intercourse after taking it. Report such instances to the doctor immediately.

For german readers:

Mit uns finden Sie ein diskretes Onlineshop bei dem Sie all Ihre Kamagra Produkte per Nachnahme bestellen knnen. Wir sind verlsslich und schnell. Dank der Expresszustellung erhalten Sie Ihre Produkte innerhalb von 72 Stunden. Als eine Internetapotheke spezialisieren wir uns darauf, Mnner mit erektiler Dysfunktion effektiv und preiswert zu untersttzen. Unser Fokus ist der Verkauf von Generika fr Erektionsschwierigkeiten aller Art als auch die Behandlung vorzeitiger Ejakulation. Kundenzufriedenheit ist immer unser Ziel. Der beste Beweis dafr sind tausende Kunden, die jhrlich bei uns einkaufen.

Die Marke Kamagra hat sich bei unseren Kunden mehr und mehr beliebt gemacht. Hergestellt werden diese bei der Pharmagesellschaft Ajanta Pharma.

Super Kamagra wird zur Behandlung der erektilen Dysfunktion und der vorzeitigen Ejakulation angewendet, zwei der hufigsten sexuellen Probleme bei Mnnern. Solche Bedingungen treten bei Mnnern ab 40 Jahren hufiger auf und schaffen so die Bevlkerungsstruktur fr Super Kamagra. Dieses Medikament ist ein starkes und wirksames Arzneimittel, das Dapoxetin und Sildenafilcitrat enthlt, um die Erektion und die Leistung im Bett zu frdern.

Das vielleicht beste Beispiel fr ein solches Produkt ist Kamagra, das in ganz Europa ber das Internet und ber den Einzelhandel als Pseudogenerikum verkauft wird und den gleichen Wirkstoff enthlt wie Pfizers Markenname Erectile Dysfunction Viagra (Sildenafil).

Nebenwirkungen
Wichtige und kleine Nebenwirkungen fr Kamagra Gold 100 MG Tablet

Kopfschmerzen – stark
Splung
Blutige Nase
Verdauungsstrungen – schwerwiegend
Schlaflosigkeit
Durchfall
Schwindel – stark
Blutiger und trber Urin – schwerer
Brennen, Taubheitsgefhl, Kribbeln in Armen und Fen – schwerwiegend
Sehstrungen – schwer – selten
Lichtempfindlichkeit – stark – selten
Lngere und schmerzhafte Erektion – schwer – selten
Schmerzhaftes Wasserlassen – schwer

Die Wirkung dieses Arzneimittels kann innerhalb von 30 bis 120 Minuten nach der Verabreichung beobachtet werden. Das Einsetzen der Wirkung kann von Patient zu Patient variieren.

Die Verwendung von Alkohol whrend der Einnahme von Kamagra Gold 100 MG Tablet kann die blutdrucksenkende Wirkung dieses Arzneimittels erhhen. Vorsicht ist besonders bei Patienten mit chronischem Alkoholkonsum geboten.

Wechselwirkung mit der Medizin

Amlodipin – mig
Carbamazepin – mig
Clarithromycin – schwerwiegend
Dexamethason – mig
Ketoconazol – schwerwiegend
Atazanavir – schwer
Nitroglycerin – schwerwiegend

Die folgenden Produkte sind in unserer Onlineapotheke (Kamagra Online-Shopping DE Potenzmittel) erhltlich: Kamagra original Tabletten, Kamagra Oral Jelly, Super Kamagra. Daneben haben Sie aber auch die Wahl, zahlreicher, anderer renommierten und viel getesteten Produkte.

Disclaimer: this article is for general informations purpose, please check with a doctor and also check if any medication is legal in your country.

Health , ,

Blockchain use cases

Waltonchains RFID technology is being used by a Smart Waste Management System in China. Using Waltons blockchain, the project will enable supervision of waste levels to improve operational efficiencies and optimize resources.

Entertainment blockchain examples : GutsA transparent ticketing ecosystem that uses blockchain technology to eliminate ticket fraud and the secondary ticket market.

Blockchain in retail : WarranteerA blockchain application that allows consumers to easily access info regarding the products they purchased and get service in the case of product malfunction.

Logistics and supply blockchain cases : IBM BlockchainKnowing the status and condition of every product on your supply chain from raw materials to distribution is critical. Blockchain for supply chains allows transparency with a shared record of ownership and location of parts and products in real time.

Insurance : Proof of insuranceNationwide insurance company is currently testing a blockchain solution to provide proof-of-insurance information called RiskBlock. Ultimately, when this tool is fully deployed it will help law enforcement, insured and insurers verify insurance coverage in real time and accelerate claims processing.

Healthcare blockchain cases : MedicalChainThe first healthcare company using blockchain technology to facilitate the storage and utilization of electronic health records in order to deliver a complete telemedicine experience. They are real practicing doctors in the UK healthcare structure and want to change the system from within.

Realestate applications of blockchain : DeedcoinRather than a typical 6% real estate commission, Deedcoin runs on 1% and hopes to be the new way for home buyers and sellers to connect with real estate agents who accept a lower commission.

As a heavily industrialised nation, Chinas environmental footprint is substantial. In March 2017, IBM launched the Hyperledger Fabric blockchain in conjunction with Energy-Blockchain Labs, as a means of tracking carbon assets in China. This creates a measurable and auditable system for tracking emissions, and facilitates a tradable market for companies seeking to offset their energy consumption whilst incentivizing greener industrial practises.

More examples at Blockchain use case – LeewayHertz Blockchain Developers.

Colored eye contacts

Gas permeable lenses – also called GP or RGP lenses – are rigid contact lenses that look and feel like PMMA lenses (see below) but are porous and allow oxygen to pass through them. Because they are permeable to oxygen, GP lenses can be fit closer to the eye than PMMA lenses, making them more comfortable than conventional hard lenses. Since their introduction in 1978, gas permeable contact lenses have essentially replaced nonporous PMMA contact lenses. GP contacts often provide sharper vision than soft and silicone hydrogel contacts – especially if you have astigmatism. It usually takes some time for your eyes to adjust to gas permeable lenses when you first start wearing them, but after this initial adaptation period, most people find GP lenses are as comfortable as hydrogel lenses.

Nowadays most people wear soft contact lenses made of a moisture-rich material called hydrogel. Hydrogel lenses are breathable, so oxygen can pass through them to help keep your eyes healthy and feeling fresh.

There are different types of contact lenses available to suit your individual vision and lifestyle needs. Your eye care practitioner can help you choose the right type of contact lens for you. Read more on Korean contact lenses

Once you have your contact lens prescription, the cards are in your hands. Have a couple brands you’ve heard of but can’t seem to choose? Not to fear. Contact lens companies often offer a “one box free” contact lens trial, so feel free to reach out to a couple of brands before settling with your favorite. Remember, the relationship can only help you if you help yourself first.

Extended wear lenses. You can wear extended wear soft contact lenses while you sleep, but they must be removed for cleaning and disinfecting at least once a week. It’s important to be cautious with overnight use, though, since it increases the risk of eye infections.
Disposable lenses. These lenses are typically more expensive. You wear the lenses during the day and remove them at night. They don’t need to be cleaned or disinfected. You use them for the recommended time frame – such as daily, weekly or monthly – and discard them. You might consider disposable lenses if you wear contacts only occasionally, you can’t tolerate disinfecting solution or you place a premium on convenience.

Avoiding complications : Practice good hygiene. Use clean hands when handling your contacts. Wash your hands with soap and water, rinse and dry them with a lint-free towel.

KPOP2 circle lenses are sold in more than 237 stores in South korea. (August, 2018)

KPOP2 is South Korea’s biggest online and offline circle lenses store. All circle lenses for sale are made in South Korea and have received authorizations from Korean FDA; they are safe to use.

We also design and manufacture tens of products. All products are made in Korea and have received authorizations from Korean FDA. The sandwich technology applied to all of KPOP2’s products ensures the quality.

KPOP2 carries 700 different kinds of cheap circle lenses.We also design and manufacture tens of products. Some of our products are designed and manufactured directly by us.

The sandwich technology was applied to all of our products to ensure high quality. The items we carry are also favorites of Korean girl & boy celebrities.

We are glad to provide fast services and affordable products to our customers all over the world via online shopping store. We hope you join in and enjoy our services.

Contact Info:
https://www.kpop2.com/
+82-70-4135-2115
YoungDong Building,
Gangnam-daero 622,
Gangnam-gu,
Seoul, Republic of Korea

Stem Cell therapy will help heart failure patients regain health

The International Forum on Heart Failure and Stem Cell Therapies Focus on C-Cure Technology and Launch Ceremony of Phase III Multisite Clinical Trial in China was held jointly by six organizations including Experts Committee of China Council for Medicine International Promotion, National Stem Cell and Regenerative Medicine Industrial Technology Innovation Strategic Alliance, etc on August 25th in Shanghai. The reporter was informed from the forum that the C-Cure technology for the treatment of heart failure through stem cells will make the heart failure patients who are lack of effective treatment regain health and rebirth.

Junbo Ge, Academician from the Chinese Academy of Sciences and Deputy President of Tongji University, has introduced the current situation of heart failure worldwide on the forum, that is, the number of patients worldwide reaches 117 million, among which there are 29.971 million patients in China, accounting for 25.6% of the total. At present, the traditional therapy of end-stage heart failure requires heart transplantation, which not only arouses problems such as too less donors, long waiting time, strong rejection reaction, etc, but also brings huge economic burden to the family or even the society. Academician Ge also says that the scientists are still making unremitting efforts to promote the application of stem cell technology on Chinese people suitably and safely. He also hopes that more administrative departments will support this technology and he believes the future will definitely be the biomedical era.

Dr Andre Terzic from the Center for Regenerative Medicine of the US Mayo Clinic and the experts from the Cardiovascular Center of Belgian Aalst Hospital have introduced the cardiac repair revolution of stem cell technology——C-cure technology and C-CathEZ Catheter on the forum. The C-Cure technology involves aspiration of the patient’s bone marrow and isolation of the mesenchymal stem cell fraction. A unique and proprietary “cardiopoietic cocktail” of proteins is used to differentiate the patient’s mesenchymal stem cells into cardiac progenitor cells, or so called “cardiopoietic cells”. The heart specific stem cells are expanded in vitro and then implanted into the diseased and damaged area of the heart using the C-Cathez delivery device. These implanted cardiac stem cells regenerate and heal the heart that has been injured by myocardial infarction, or heart attack.

C-CathEZ is the world’s most advanced proprietary catheter used for delivery of stem cells to the heart. It is capable of accurately delivering diagnostic and therapeutic agents to the damaged myocardium through a minimally invasive procedure. C-CathEZ navigates to the left ventricle through the aortic arch, and its curved and porous needle stays anchored to the ventricular wall, moving in sync with the ventricular wall motion once it reached the myocardium. The porous needle can also be repositioned for injections of cells into different areas. C-CathEZ enables the injection and distribution of stem cells evenly into the damaged myocardium, resulting in a higher portion of retention of cells. The C-Cure technology and the catheter C-CathEZ have been nominated as finalists for two 2014 European Mediscience Awards, the “Breakthrough Award” and the “Best Technology Award”.

Medisun has established collaborations with the Mayo Clinic, a renowned medical group in the United States, and the two have co-invested in Cardio3 BioSciences, the owner of C-Cure technology and catheter C-CathEZ. At present, C-Cure has been authorized to conduct the Phase III clinical trial in the US and European Union, and the product could potentially be launched globally in 2016. Moreover, the technology of catheter C-CathEZ has obtained authentication and licensing from the EU in April, 2012.

In order to make the stem cell therapy be available to more Chinese heart failure patients, Mesisun Holdings Limited will establish 8 to 10 international multisite clinical bases in Shanghai, Beijing and Guangzhou to carry out the Phase III clinical trial of C-Cure technology in Mainland China. The launch ceremony of developing Phase III clinical trial by the cooperation of Cardio3 and Shanghai East Hospital has been held on the forum. Before that, Medisun Holdings Limited and Beijing Anzhen Hospital has formally launched the cooperation of Phase III clinical trial of C-Cure technology.

Zhongmin Liu, President of the East Hospital of Tongji University says, “The clinical application of stem cell is the dream of a number of clinical doctors and the experts from the stem cell field. With the gradual improvement of the isolation, culture and expansion technology of stem cells as well as the interventional methods for heart failure patients, the clinical application is promising. The East Hospital is looking for a biological cell therapy with more effectiveness and better life quality for the patients, which is able to avoid and delay the heart transplantation, that is, the application of stem cells in the heart failure treatment. Before the stem cell therapy, the heart failure patients rely on the heart transplantation ultimately. However, the time to wait for the heart donor is long, and the patient has to be hospitalized repeatedly, which costs money and makes the patient painful. With this cell technology, combining with technology of minimally invasive catheter, the result of HF treatment may be identified whenever or wherever without spending too much money. It can avoid the patients to be hospitalized repeatedly and can also reduce expenditure, which brings better life for the patients. This cell therapy brings effects that the traditional drug treatment can’t give not only for HF patients, but also for patients with diabetes, stroke, osteoarthritis, etc in the future. Therefore, the cell treatment including stem cell treatment will be the pillar industry which will be focused on to develop not only in China, but also in developed countries such as the United States, and it will certainly lead the new revolution in medical industry.

In addition, the Stem Cell Clinical Trial Management Approach will be issued in the second half of this year. We can believe that the support of relevant departments in China will certainly promote the regenerative medicine of stem cell to develop rapidly and normatively for the benefit of Chinese people.

Notes:

Medisun Holdings Limited: Medisun plans to invest in stem cell regenerative technology and products worldwide, focusing on cardiovascular diseases and other serious diseases, including cancer (leukemia, malignant lymphoma, etc.), lung disease, liver disease, kidney disease, diabetes, autoimmune disease, nerve system disease, stroke and spinal cord injury. Medisun is committed to uncovering the power of regenerative technology in treating human diseases and promoting it as the mainstay of future medicine.

Mayo Clinic: Headquartered in Rochester, Minnesota, USA, Mayo Clinic marks 150 years of service to patients in 2014. As a medical group with integrated treatment and care, medical school instruction and scientific research, Mayo is highly regarded by the international medical community and has been at or near the top of the U.S News & World Report list of “Best Hospitals” for more than 20 years. For more than a century, Mayo Clinic has been a leader in the research and development of new therapies, innovation in hospital maganement and next generation telemedicine, and it is sometimes referred as the “Supreme Court” of medicine. Today, Mayo Clinic has branches in Florida and Arizona, its own medical school and dozens of clinics in the surrounding states. It employs more than 3,800 physicians and scientists ans 50,900 allied health staff, with an annual revenue of nearly US$ 10 billion.

Affiliated companies established by Medisun in Asia and China

Cardio3 BioSciences Aisa Holdings Limited will be sponsoring the Phase III clinical development and commercialization of C-Cure for ischemic heart failure and other stem cell-based regenerative products. The company plans to enter the Japanese market with an expected launch of a clinical trial in 2015, followed by introduction into markets including India, Indonesia, etc. where the population is over 20 million.

Cardio3 BioSciences (China) Co., Ltd will be sponsoring the Phase III clinical development and commercialization of C-Cure in China.

Source : http://www.medisun.hk/

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